J Korean Acad Periodontol.  2006 Jun;36(2):289-303. 10.5051/jkape.2006.36.2.289.

Histologic evaluation of the regenerated bone using bone graft materials

• Ryu HC
• Park JB
• Kwon YH
• Herr Y
• Chung JH
• Jue SS

• KMID: 1711839
• DOI: http://doi.org/10.5051/jkape.2006.36.2.289

Abstract

This study was performed to evaluate the effect of bone graft materials including demineralized freeze-dried bone, freeze-dried bone, deproteinized bovine bone on space-making capacity and bone formation in guided bone regeneration with titanium reinforced ePTFE membrane(TR-ePTFE). Adult male rabbits(mean BW 2kg) were used in this study. Intramarrow penetration defects were surgically created with round bur on calvaria of rabbits. TR-ePTFE membrane was adapted to calvarial defect and bone graft materials were placed. Animals were sacrificed at 2, 8, 12 weeks after surgery. Non-decalcified specimens were processed for histologic analysis and prepared with Villaneuva bone stain. The results of this study were as follows: 1. TR-ePTFE membrane was biocompatible and capable of maintaining the space-making. 2. Tissue integration was not good at TR-ePTFE membrane. Fixation was not enough. so, wound stabilization was not good. 3. In animals using deproteinized bovine bone, demineralized freeze-dried bone, bone formation was little. 4. In animals using freeze-dried bone, bone formation was better. Within the above results, bone formation may be inhibited when wound stabilizafion was not good.

Keyword

Guided bone regeneration; Titanium reinforced ePTFE membrane; Bone graft materials

MeSH Terms

Adult
Male
Female
Humans
Rabbits
Animals