J Korean Assoc Oral Maxillofac Surg.  2001 Apr;27(2):103-110.

On the Activity of MC3T3-E1 Cell in vitro

Affiliations
  • 1Department of Oral & Maxillofacial Surgery, College of Dentistry, Kyung-Hee University.

Abstract

This study was performed to observe the effect of ultrasound(1.0MHz, 0.75W/cm2 and 1.0W/cm2) irradiation on cultured MC3T3-E1 cell, osteoblastic like cell with respect to the proliferation, protein synthesis, and alkaline phosphatase activity of the cells. The results were as follows: 1. The proliferation of MC3T3-E1 cells was increased on ultrasound irradiated group compared with control group. 2. The protein synthesis was not apparently increased on ultrasound irradiated group compared with control group. 3. The alkaline phosphatase activity level was not apparently increased on ultrasound irradiated group compared with control group. From the above results and other literatures, we could suggest that the ultrasound with the appropriate intensity and frequency may have important roles in stimulation of cell proliferation. Therefore the ultrasound may be used in the acceleration of the bone regeneration and bone fracture healing.

Keyword

Ultrasound; MC3T3-E1 cell; Bone regeneration

MeSH Terms

Acceleration
Alkaline Phosphatase
Bone Regeneration
Cell Proliferation
Fractures, Bone
Osteoblasts
Ultrasonography
Alkaline Phosphatase
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