J Korean Assoc Maxillofac Plast Reconstr Surg.  1997 Feb;19(1):15-24.

Histological Comparative Study of Chided Bone Regeneration With Gore-Tex(TM) Membrane and Collacote(R)

• Kim TK
• Jang CD
• Kim CH

Abstract

The principle of guided tissue regeneration (GTR), as applied to bone healing is based on the prevention of connective tissue from entering the bony defect during the healing phase. This allows the slower bone producing cells to migrate into and reproduce bone within the defect. GTR has demonstrated a level of success in regenerating bone defect. Several types of membrane barrier have been utilized to apply this principle in bone regeneration, The purpose of this study was to evaluate whether improved bone regeneration can be achieved with different membrane barriers (Gore-TexTM membrane, COLLACOTER). In the 10 NewZealand white rabbits, full-thickness bone defects on three sites of each rabbit calvaria were made. Experimental group 1 was covered with COLLACOTER, and group 2 was covered with Core-Tex TM membrane. Macroscopic, microscopic examinations were made serially on 1, 2, 3, 6, 12 weeks after operation. The results were as follows : 1. Macroscopically, both of experimental group 1, 2 were filled with bone-like mass but the defects of experimental group 1 disclosed markedly thinner than the original bone. 2. Microscopically, the defect of experimental group 1, 2 was filled with bony trabeculae without-infection and adverse reaction. But multinucleated giant cell infiltration around COLLACOTER was seen till 6th week. 3. Resorption of COLLACOTER started from 3rd week and it was completely resorped on the 12th week.

MeSH Terms

Bone Regeneration*
Connective Tissue
Giant Cells
Guided Tissue Regeneration
Membranes*
Rabbits
Skull