J Korean Acad Periodontol.  1997 Mar;27(1):151-163. 10.5051/jkape.1997.27.1.151.

Evaluation of biodegradability and tissue regenerative potential of synthetic biodegradable membranes

Affiliations
  • 1Department of Periodontology, College of Dentistry, Seoul National University and Dental Research Institute, Korea.

Abstract

The purpose of this study was to evaluate on the biodegradability, biocompatibility and tissue regenerative capacity of synthetic biodegradable membranes-Resolut(R), Guidor(R) and Biomesh(R). To evaluate the cell attachment on the membranes, in vitro, the number of gingival fibroblasts attached to each membrane was counted by hemocytometer. Cytotoxicity test for the membranes was performed by MTT test with gingival fibroblast For evaluation of guided bone regenerative potential, the amount of new bone formation in the rat calvarial defects(5mm in diameter) beneath the membranes was observed for two weeks and examined of the specimens by Massons trichrome staining. Biodegradability was observed for 2, 4, 8 and 12 weeks after implantation of each materials under the skin of rats and examined the specimens with H & E staining. The number of cell attachment were the greatest in Biomesh(R) and followed by Resolut(R). Cell viability of three membranes was almost similar levels. Biodegradability of Resolut(R) was the highest among three membrane and the potential of guided bone regeneration was the greatest in the Biomesh(R) and Resolut(R) was followed. These results suggested that commercially available biodegradable membranes were non-toxic and highly potential to guided bone regeneration.

Keyword

synthetic biodegradable membrane; biodegradability; biocompatibility; tissue regenerative capacity; guided bone regeneration

MeSH Terms

Animals
Bone Regeneration
Cell Survival
Fibroblasts
Membranes*
Osteogenesis
Rats
Skin
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