J Korean Neurosurg Soc.
1989 Jun;18(6):827-835.
The Study on Vascular Reactivity to Vasoactive Agents in Isolated Porcine Cerebral Artery
- Affiliations
-
- 1Department of Neurosurgery, School of Medicine, Wonkwang University, Iksan, Korea.
Abstract
- The present in vitro experiments were performed to investigate the contractile activity and action sites of various vasoactive agents on isolated porcine internal carotid artery as a preliminary study on cerebral arterial spasm. The cumulative dose-response curves were obtained for most vasoactive agents such as serotonin and adrenergic drugs including agonists and these effects were investigated under antagonists in isolated arterial rings. The results of this study suggest that serotonin is the most potent agent for the cerebral arterial spasm, and there are alpha-adrenoceptor and serotonin receptor mediating vasoconstriction and beta-adrenoceptors mediating vasodilation in porcine internal carotid artery. The cross reactivity between alpha-adrenoceptor and serotonin receptor suggests that the two types of receptors have common features which will be further investigated.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Development of an Ex Vivo Model for the Study of Cerebrovascular Function Utilizing Isolated Mouse Olfactory Artery
- Contractile Response to Endothelin in Porcine External Carotid Arteries
- Microsurgical anatomy of the Anterior Cerebral-anterior Communicating Artery
- Effect of Heat Shock on the Vascular Reactivity and Expression of Heat Shock Protein in an Animal Model of Type 2 Diabetes Mellitus (OLETF rat)
- Contractile effects of hemoglobin-free human cerebrospinal fluid on isolated porcine cerebral arteries
