J Korean Ophthalmol Soc.  1988 Aug;29(4):611-618.

Prostaglandin E in Rabbit Aqueous Humor After Nd-YAG Laser Photodisruption of Iris and the Effect of Topical Indomethacin Pretreatment

• Joo CK
• Kim JH
• Shim BS

Abstract

Rabbit eyes were irradiated with neodymium-yttrium-aluminum-garnet(Nd-YAG) laser and the changes of prostaglandin E and protein levels in aqueous humor were measured. Intraocular pressure and pupil diameter were also determined in the same rabbits. Prostaglandin E and protein in aqueous humor were increase depending upon the number of laser lesion. Increase of intraocular pressure and decrease of pupil diameter occurred at similar dose range of laser irradiation. Tesponse of iris to the photodisruption was rapid. Changes in prostaglandin and protein contents and pupil diameter were already prominent at 15 min after the laser irradiation. Indomethacin pretreatment abolished most of tese responses, suggesting that acute reactions following photodisruption were largely dependent on prostaglandin synthesis in iris tissure.

MeSH Terms

Aqueous Humor*
Indomethacin*
Intraocular Pressure
Iris*
Lasers, Solid-State*
Pupil
Rabbits
Indomethacin