J Korean Ophthalmol Soc.  1987 Jun;28(3):589-593.

Studies of the Timolol Effect on Intraocular Pressure and Concentration in Aqueous Humor in the White Rabbit

• Oh YD
• Kwak HW
• Kim JM

Abstract

The effect of 0.25% and 0.5% Timolol on intraocular pressure and concentration in aqueous humor was studied after topical instillation in the white rabbit. The intraocular pressure was measured with pneuma tonometer and the Timolol concentration in aqueous humor was measured with High Preformance Liquid Chromatograph after fine needle aspiration of aqueous humor at various time intervals. The results were as follows; 1. The percentage reduction of intraocular pressure increased with time and reached a peak after 3 hours. 2. The concentration of Timolol in aqueous humor increased with time and reached a peak after 3 hours. 3. There was close correlation between intraocular pressure and Timolol concentration in aqueous humor.

MeSH Terms

Aqueous Humor*
Biopsy, Fine-Needle
Intraocular Pressure*
Timolol*
Timolol