J Korean Soc Ther Radiol.
1990 Dec;8(2):151-154.
Acute Response to Co-60 Total Body Irradiation (TBI) With 600 cgy at 3 Different Does Rates in the Mice
- Affiliations
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- 1Department of Therapeutic Radiology, College of Medicine, Yeungnam University, Taegu, Korea.
Abstract
- The acute effects of variable dos rates to total body irradiation (TBI) were investigated with 600 cgy of single exposure in the mice as a preclinical model. Total 80 mice (ICR) were used. Twenty of which served as controls, receiving no irradiation. All irradiated mice showed a universal decline in their weight and white blood cell count. The degree of weight loss and leukopenia were similar at 3 different dos rate but slightly prominent with 15 cgy/minute group. The degree of recovery among the groups showed no dose rate dependence. Our results suggest that TBI with 15 cgy/minute may be applicable for clinical therapy with careful evaluation of patient's condition.
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