J Korean Surg Soc.
2002 Feb;62(2):181-186.
Vascular Diseases Associated with Protein C and/or S Deficiencies
- Affiliations
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- 1Department of Surgery, Asan Kangnung Hospital, Kangnung, Korea.
- 2Department of Diagnostic Radiology, Asan Kangnung Hospital, Kangnung, Korea.
Abstract
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PURPOSE: There are a number of conditions that can lead to a hypercoagulable state, however, protein C and S deficiencies are frequently described as causes of the hypercoagulable states. The aim of this study was to evaluate the clinical features and prognosis of vascular diseases associated with protein C and/or S deficiencies and to determine an adequate treatment modality for such cases.
METHODS
We prospectively evaluated 7 cases with vascular disease caused by protein C and/or S deficiencies confirmed with serologic tests.
RESULTS
Four patients showed venous thrombosis, 1 peripheral arterial insufficiency, 1 cerebral venous thrombosis and peripheral arterial insufficiency, and 1 portal vein thrombosis. Surgical intervention was required in 5 patients. Full anticoagulation with heparin sodium followed by warfarin sodium was done in all patients.
CONCLUSION
Protein C and S deficiencies may influence clinical management. Patients presenting with atypical vascular involvement without evidence of other risk factors should be evaluated for a hypercoagulable state. Once the diagnosis is made, patients should be treated with full anticoagulation.
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