Korean J Anesthesiol.  2006 Mar;50(3):272-277. 10.4097/kjae.2006.50.3.272.

Entropy Responses to Endotracheal Intubation during Anesthetic Induction Using Thiopental or Propofol and Succinylcholine

• Baek CW
• Ko NY
• Gwak MJ
• Park JW
• Jung YH
• Woo YC
• Kim JY
• Koo GH
• Park SG

• KMID: 1936726
• DOI: http://doi.org/10.4097/kjae.2006.50.3.272

Abstract

BACKGROUND: Thiopental and propofol are commonly used intravenous induction agents and entropy is a new method of assessing depth of anesthesia. In this study we evaluated the entropy responses to endotracheal intubation during anesthetic induction with thiopental or propofol.
METHODS
Forty ASA class I and II adult female patients undergoing elective surgeries were enrolled into this randomized, prospective study. At 1 minute after fentanyl 2 microgram/kg, thiopental 5 mg/kg (group T) or propofol 2 mg/kg (group P) was administered for induction. And endotracheal intubation was performed following succiny choline 1 mg/kg. From pre-induction till post-intubation 10 minutes, the entropy and hemodynamic variables were measured and compared.
RESULTS
The entropy following intubation increased significantly in both groups. But entropy changes in group T were greater than those in group P remained below 65.
CONCLUSIONS
Our results using the entropy to monitor anesthetic depth during induction and intubation, suggest that thiopental 5 mg/kg is more likely to be associated with lighter planes of anesthesia and consequent risk of arousal reaction following endotracheal intubation than propofol 2 mg/kg.

Keyword

entropy; intubaion; propofol; thiopental

MeSH Terms

Adult
Anesthesia
Arousal
Choline
Entropy*
Female
Fentanyl
Hemodynamics
Humans
Intubation
Intubation, Intratracheal*
Propofol*
Prospective Studies
Succinylcholine*
Thiopental*
Choline
Fentanyl
Propofol
Succinylcholine
Thiopental