Korean J Anesthesiol.  1987 Jun;20(3):354-357. 10.4097/kjae.1987.20.3.354.

Epidural Ketamine for Control of Postoperative Pain

• Choi R
• Woo NS
• Um DJ
• Kil HK

• KMID: 1933290
• DOI: http://doi.org/10.4097/kjae.1987.20.3.354

Abstract

In recent years the use of epidural opiates has increased and although this method of pain relief has shown good results in clinical practice it is still subject to certain drowba-cks, the most serious of which appears to be delayed respiratory depression. Since ketamine administered systemically is unlikely to produce respiratory depression it seemed worthwhile to investigate the possibility of exploiting the potent analgesic property to ketarnine by its epidural administration. The analgesic effect of ketamine 4 mg, administered epidural space, was evaluated. The duration of pain relief varied from less than 3 hours in 20% to over 24 hours in 30 % of the cases. In 62.5% of the cases pain relief exceeded 6 hours. There was no evidence of respiratery depression, and there no postoperative neurologic sequelae. The present results indicated the need for farther studios to compare the efficacy and safety of epidural ketamine with the response to epidural opioids for the relief of posto- peratiue pain.

MeSH Terms

Analgesics, Opioid
Depression
Epidural Space
Ketamine*
Pain, Postoperative*
Respiratory Insufficiency
Analgesics, Opioid
Ketamine