Korean J Anesthesiol.  1988 Aug;21(4):555-563. 10.4097/kjae.1988.21.4.555.

Antihypertensive Effects of Nasal Administration of Nifedipine in Patients Anesthetized with Diethyl - Ether

• Nam KY
• Park YC
• Shin DH
• Baik SW
• Kim IS
• Chung KS

• KMID: 1933126
• DOI: http://doi.org/10.4097/kjae.1988.21.4.555

Abstract

The effect of intranasal nifedipine drops in 20 randomly chosen patients with diethyl-ether induced hypertension by inhalation anesthesia was observed. Patients were placed in two groups: the first group received intranasal nifedipine at the time of induction and the second group received intranasal nifedipine at the time to skin incision. The change in mean arterial pressure in the first group was not significant, but in the second group, the increase in mean arterial pressure was significant immediately after intranasal administration of nifedipine at the time of skin incision. An increase in pulse rate was noted with the increase in mean arterial pressure and this is thought to result from the stimulation of catecholamine secretion and baroreceptor reflex. Since the difference in mean arterial pressure between the two groups was minimal at ten minutes and twenty minutes after skin incision, it is suggested that the onset of intranasal nifedipine is quite fast. Based on the authors' experience, intranasal administration of nifedipine is very useful in preventing or treating hypertension during inhalation anesthesia using diethyl-ether.

Keyword

Hypertension; intranasal nifedipine; Diethyl-ether

MeSH Terms

Administration, Intranasal*
Anesthesia, Inhalation
Arterial Pressure
Baroreflex
Ether*
Heart Rate
Humans
Hypertension
Nifedipine*
Skin
Ether
Nifedipine