Korean J Blood Transfus.  1995 Dec;6(2):185-188.

A Case Report of Anti-Jr(a) in Pregnant Woman

• Kim HK
• Park Q
• Nahm CH
• Kwon OH
• Park YW

Abstract

The high incidence antigert Jr" was first identified in 1970 by Stroup and Macllroy. Anti-Jr~ was immune antibodies developed by transfusion or pregnancy and occasionally cause hemolytic disease of the newborn and transfusion reaction, but these usually mild. We are reporting the first case of anti-Jra in Korea, which was identified in pregnant woman with transfusion history. The 35 year old pregnant woman(G6P4L1D3A1) admitted to treat for incompetent internal os of cervix on department of Obstetrics and Gynecology. Prenatal irregular antibody screening was negative. One unit of RBC was transfused at 21 gestational weeks for correction of anemia. One week later, irregular antibody was detected in her serum. The antibody reacted best by indirect antiglobulin test and panagglutinated all identified cells. The titer was 1 : 8. The antibody was identified as anti-Jr by Dr. Osaka Red Cross Center. Her phenotype of Jra was Jr(a-), but there was no Jr(a-) person in her family. She might have anti-Jra in her serum with undetectable level due to multiple pregnancies. In this case, the development of anti-Jr was stimulated by one unit of RBC transfusion with anamnestic reaction. The titer of anti-Jr was gradually reduced during pregnant period. She delivered at 37 gestational weeks by cesarian section. The baby was clinically well at birth and typed as Jr(a+).

MeSH Terms

Adult
Anemia
Antibodies
Blood Group Incompatibility
Cervix Uteri
Coombs Test
Female
Gynecology
Humans
Incidence
Infant, Newborn
Korea
Mass Screening
Obstetrics
Parturition
Phenotype
Pregnancy
Pregnancy, Multiple
Pregnant Women*
Red Cross
Antibodies