Korean J Thorac Cardiovasc Surg.
1999 Feb;32(2):151-157.
Correlation Between Apoptosis and Intratumoral Microvessel Density in Non-Small Cell Lung Cancer
- Affiliations
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- 1Department of Thoracic and Cardiovascular Surgery, College of Medicine Hospital, Gyeong Sang National University, Gyeong Sang National University Hospital.
- 2Department of Throacic and Cardiovascular Surgery, College of Medicine, Sung Kyun Kwan University, Samsung Medical Center.
- 3Department of Diagnostic pathology, College of Medicine, Sung Kyun Kwan University, Samsung Medical Center.
Abstract
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BACKGROUND: Increasing evidences from experimental studies indicate that apoptosis may be inversely related to angiogenesis in tumor progression.
MATERIAL AND METHOD: To explore how apoptosis correlates with tumor angiogenesis, we measured the apoptotic index(AI) using the terminal deoxynucleotidyl transferase method(Apop Tag In Situ Apoptosis Detection Kit, ONCOR) and the intratumoral microvessel density using the anti-CD31 monoclonal antibody in non-small cell lung cancer.
RESULT: Statistical analysis revealed an inverse correlation between AIs and intratumoral microvessel densities in squamous cell lung carcinoma(Spearman rank correlation coefficient r=- 0.229, p=0.047).
CONCLUSION
The results of this study demonstrated that the amount of apoptosis in squamous cell lung carcinoma may be influenced by the extent of neovascularization. This suggests that tumor angiogenesis may contribute to a reduction of apoptosis in tumor cells.
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