Study on Uric Acid Level in Urinary Calcium Stone Formers

Ryu, Youn Kil; Min, Byung Kap

Abstract

This study was aimed to clarify whether urinary calcium stones may be associated with uric acid disorders. Serum uric acid concentrations and 24-hour urinary excretion of uric acid were determined in 73 calcium stone formers and in 60 controls. The following results were obtained: 1. The mean values of serum uric acid were 4.59+/-0.84 mg/dl in male controls and 4.07+/-1.21 mg/dl in female controls, 5.36+/-1.34 mg/dl in male stone formers and 4.87+/-1.34 mg/dl in female stone formers. Serum uric acid concentrations of male stone formers were significantly higher than those of male controls. 2. The mean values of 24-hour urinary excretion of uric acid were 644.1+/-313.4 mg in male controls and 510.0+/-2256.7 mg in female controls, 808.7+/-411.7 mg in male stone formers and 701.9+/-278.4 mg in female stone formers. The 24-hour urinary excretion of uric acid of male stone formers were significantly higher than those of male controls. 3. Hyperuricemia was observed in non of male and female controls, 10.9% of male stone formers and 14.8% of female stone formers. 4. Hyperuricosuria was observed in 22.4% of male controls and 18.2% of female controls, 45.7% of male stone formers and 40.7% of female stone formers. Hyperuricosuria was more frequent in male stone formers. 5. The incidence of patients with hyperuricemia and/or hyperuricosuria was observed in 21.7% of controls and 50.7% of calcium stone formers. The result, that patients with calcium stone disease were hyperuricemic and hyperuricosuric more often than controls suggested that some urinary calcium stones may be associated with uric acid disorders.