Studies on Uric Acid Disorders in Patients With Upper Urinary Calculi

Hwang, Chi Il; Yoon, Jong Byung

Abstract

We studied tire causative diseases and serum concentration and daily urinary excretion of uric acid in 115 cased of radiopaque upper urinary stone formers. And with the aim of establishing methods for the prevention of recurrent stone formation, allopurinol and/or sodium bicarbonate was administered to hyperuricemia and/or hyperuricosuria. The following results were obtained. 1. 25 of 115 cases having uric acid abnormality in serum and/or urine, it was some correlation on between hyperuricemia and/or hyperuricosuria and calcium formers. 2. 14 of 25 cases administering allopurinol and/or sodium bicarbonate after lithotomy had not recurrent stone formation for 1-2 years. But of 11 cases receiving medical treatment alone only 2 cases were spontaneously evacuated the stones, 3 cases were decreased in number of stones, 6 cases were not changed. 3. After administration of allopurinol serum uric acid, daily urinary uric acid daily urinary calcium and daily urinary inorganic phosphorus value were significantly decreased but serum calcium and inorganic phosphorus were not significantly changed. These results suggested that allopurinol was effective or prevention of recurrent stone formation, even through our studies were relatively short period and not many cases.