Biochemical Characteristics of Serum and Urine in the Patients with Uric Acid Stone

Lee, Min Woo; Jeong, Young Beom; Kim, Young Gon

Abstract

PURPOSE: We investigated the biochemical characteristics of serum and urine in the patients suffering with uric acid stone.
MATERIALS AND METHODS
A total of 99 patients suffering with uric acid stone underwent routine urine analysis and 24-hour urine analysis for determining the urinary calculi risk factors. We conducted serum analysis for the stone risk factors and also analysis of the stone analysis. To compare the stone risk factors, 93 patients with calcium stone were identified and then the biochemical risk factors in the serum and urine were evaluated.
RESULTS
The mean age of patients with uric acid stone was 56.5+/-12.4 years and the mean age of the patients with calcium stone was 40.2+/-11.5 years. Serum uric acid, cholesterol and triglyceride were all significantly increased in the patients with uric acid stone compared to that in the patients with calcium stone. The patients with uric acid stone showed a lower urinary pH and also lower urinary uric acid and citric acid excretion compared with those patients with calcium stone. The composition of the uric acid stone was mixed with calcium in 63.6 percent of the stones and 36.4% of the stones were pure.
CONCLUSIONS
The patients with uric acid stone had higher serum uric acid, cholesterol and triglyceride, and they had a lower urinary pH and lower uric acid and citric acid excretion as compared with the patients with calcium stone. Uric acid-calcium mixed stone was most common in the patients with uric acid stone. There is a great likelihood of uric acid stone in the patients with stone who have one or more of the above mentioned biochemical characteristics. Therefore, these factors are important to conduct metabolic evaluation for preventing stone recurrence.