Korean J Blood Transfus.
2007 Dec;18(3):244-248.
A Case of Group O Losing Anti-B Selectively
- Affiliations
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- 1Department of Laboratory Medicine, Ulsan University Hospital, Ulsan, Korea. srkimuuh@hitel.net
- 2Korean Red Cross Busan Blood Center, Busan, Korea.
- 3Department of Laboratory Medicine, Asan Medical Center, Seoul, Korea.
Abstract
- We report a case of group O losing anti-B selectively. A 25-year-old male donated blood; on the donor test an ABO discrepancy was noted, and a further evaluation study was performed. ABO genotyping with an allele specific polymerase chain reaction assay revealed O/O and DNA sequencing of exons 6 and 7 of the ABO gene showed O01/O02. The serum gammaglobulin level was decreased and only 0.2% CD19 pan-B positive lymphocytes were present in a subset of lymphocytes. In a previous donor study, anti-B of the patient was lost from a third donor study and was still not detected.
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