J Korean Radiol Soc.
2006 May;54(5):385-391. 10.3348/jkrs.2006.54.5.385.
Detection of the Anatomic Structure and Pathology in Animal Lung Specimens: Comparison of Micro CT and Multi-Detector Row CT
- Affiliations
-
- 1Department of Radiology, National Cancer Center, Korea. imjg@radcom.snu.ac.kr
- 2Department of Radiology and Clinical Research Institute, Seoul National University Hospital and the Institute of Radiation Medicine, Seoul National University Medical Research Center, Korea.
- 3Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Korea.
- KMID: 1900686
- DOI: http://doi.org/10.3348/jkrs.2006.54.5.385
Abstract
- PURPOSE
We wanted to compare the capability of micro CT and the clinically available thin-slice multi-detector row CT (MDCT) for demonstrating fine anatomic structures and pathological lesions in formalin-fixed lung specimens.
MATERIALS AND METHODS
The porcine lung with shark liver oil-induced lipoid pneumonia and the canine lung with pulmonary paragonimiasis were fixed by ventilating them with formalin vapor, and they were then sliced into one-centimeter thick sections. Micro CT (section thickness, 18 micrometer) and MDCT (section thickness, 0.75 mm) images were acquired in four of the lung slices of the lipoid pneumonia specimen and in five of the lung slices of the paragonimiasis specimen. On 62 pairs of micro CT and MDCT images, 169 pairs of rectangular ROIs were manually drawn in the corresponding locations. Two chest radiologists recorded the detectability of three kinds of anatomic structures (lobular core structure, interlobular septum and small bronchiolar lumen) and two kinds of pathological lesions (ground-glass opacity and consolidation) with using a five-point scale. The statistical comparison was performed by using the Wilcoxon signed rank test. Interobserver agreement was evaluated with kappa statistics.
RESULTS
For all observers, all the kinds of anatomic structures and pathological lesions were detected better on the micro CT images than on the MDCT images (p<0.01). Agreement was fair between two observers (kappa = 0.38, p<0.001).
CONCLUSION
The fine anatomic structures and pathological lesions of the lung were more accurately demonstrated on micro CT than on thin-slice MDCT in the inflated and fixed lung specimens.
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