J Korean Soc Pediatr Nephrol.  2007 Apr;11(1):16-23.

Correlation between Serum Albumin Level and IgG Level in Minimal Change Nephrotic Syndrome

• Kwak GY
• Lee KY
• Kim DU
• Koh DK
• Lee JS

Abstract

PURPOSE: Hypogammaglobulinemia has been observed in nephrotic syndrome, but its pathophysiology remains unknown. We evaluated the relationship between the serum IgG and albumin levels for children with minimal change nephrotic syndrome(MCNS).
METHODS
The levels of immunoglobulin G(IgG), albumin and total cholesterol of a total of 46 children with MCNS(proteinuria >40 mg/m2/h, and serum albumin level <2.5 g/dL) were analyzed.
RESULTS
The mean values of albumin, IgG and total cholesterol in MCNS children were 1.7+/-0.3 g/dL, 368+/-143 mg/dL and 431+/-78 mg/dL, respectively. There was an inverse correlation between the albumin values and the total cholesterol values(r=0.68, P=0.0001), whereas there was a direct-proportional correlation between albumin values and the IgG values(r=0.4, P=0.01).
CONCLUSION
The IgG level is associated with albumin level, and it may reflect the severity of urinary protein loss in MCNS. Further studies are needed to evaluate this phenomenon.

Keyword

Nephrotic syndrome; Albumin; Cholesterol; Immunoglobuin G

MeSH Terms

Agammaglobulinemia
Child
Cholesterol
Humans
Immunoglobulin G*
Immunoglobulins
Nephrosis, Lipoid*
Nephrotic Syndrome
Serum Albumin*
Cholesterol
Immunoglobulin G
Immunoglobulins
Serum Albumin