J Korean Pediatr Soc.  1994 Sep;37(9):1245-1250.

The Roles of IgG and Albumin as a Predictor of Frequent Relapse in Nephrotic Syndrome

• Lee JH
• Kim JG

Abstract

The etiology of nephrotic syndrome in unknown. The characterization were proteinuria, hypoalbuminemia, generalized edema and hyperlipidemia. To assess the recurrence factors in the nephrotic syncrome, we measured serum immunoglobulin (IgG, IgA, IgM), albumin, complement, cholesterol and the 24-hour total urine protein at the initial relapse of nephrotic syndrome. Each data of frequent and infrequent relapsed nephrotic syndrome were compared. In total 67 cases, 18 cases were frequent relapsers and 26 cases were infrequent relapsers and 23 cases were normal control without renal disease. The levels of IgG and albumin in frequent relapser were 304 mg/dl and 1.59 g/dl as compared with 440 mg/dl and 2.06 g/dl in infrequent relapsers. The levels of IgG and albumin were signifecantly lower in frequent relapser than infrequent relapsers (p<0.05). This study might be useful to predict that very low levels of IgG and albumin at the first relapse might be related to high risk chances of frequent relapse in children with nephorotic syncrome.

MeSH Terms

Child
Cholesterol
Complement System Proteins
Edema
Humans
Hyperlipidemias
Hypoalbuminemia
Immunoglobulin A
Immunoglobulin G*
Immunoglobulins
Nephrotic Syndrome*
Proteinuria
Recurrence*
Cholesterol
Complement System Proteins
Immunoglobulin A
Immunoglobulin G
Immunoglobulins