Korean J Dermatol.
2006 Feb;44(2):190-192.
A Case of Leukoderma Punctata after Topical PUVA Therapy in Segmental Vitiligo Patient
- Affiliations
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- 1Department of Dermatology, Keimyung University School of Medicine, Daegu, Korea. dermasong@dsmc.or.kr
Abstract
- Leukoderma punctata is a rare side effect of photochemotherapy such as psoralen with solar ultraviolet light (PUVASOL) or psoralen with ultraviolet A (PUVA), and manifests as numerous discrete punctate, hypopigmented and achromic spots. Histopathologically, a focal reduction of melanocytes and melanin granules are found in the depigmented macules, revealed by S-100 and Fontana-Masson staining. The phototoxic effect of photochemotherapy on melanocytes has been suggested as the most likely cause. This occurs mostly after systemic psoralen on photochemotherapy. However, a case following topical PUVA therapy is very rare. We report a rare case of leukoderma punctata in a 6-year-old female after topical PUVA therapy for segmental vitiligo.
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