Korean J Dermatol.
2006 Oct;44(10):1191-1194.
Expression of Neuropeptides and Their Receptors in Psoriatic Lesions
- Affiliations
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- 1Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Korea. han_newtype@hotmail.com
- 2Asan Institute for Life Science, Seoul, Korea.
Abstract
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BACKGROUND: Neuroimmunocutaneous system alteration can be responsible for the induction and maintenance of the inflammatory process of psoriasis.
OBJECTIVE
This study was carried out to examine the expression of Substance P (SP), calcitonin gene-related peptide (CGRP), somatostatin (SOM), neutral endopeptidase (NEP), SP receptor, and CGRP receptor in psoriatic lesions.
METHODS
A skin biopsy was obtained from 10 psoriatic patients and 10 normal control subjects. Confocal laser scanning microscopy was performed.
RESULTS
The SP and CGRP receptors consistently increased in psoriatic lesions, compared to the normal controls.
CONCLUSION
The increased expression of neuropeptides and their receptors may be involved in the pathogenesis of psoriasis.
Keyword
MeSH Terms
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Biopsy
Calcitonin Gene-Related Peptide
Humans
Microscopy, Confocal
Neprilysin
Neuropeptides*
Psoriasis
Receptors, Calcitonin Gene-Related Peptide
Receptors, Neuropeptide
Skin
Somatostatin
Substance P
Calcitonin Gene-Related Peptide
Neprilysin
Neuropeptides
Receptors, Calcitonin Gene-Related Peptide
Receptors, Neuropeptide
Somatostatin
Substance P
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