Korean J Hepatol.  2001 Sep;7(3):341-344.

A Case of Acute Cholestatic Hepatitis Caused By the Seeds of Psoralea-corylifolia

• Hwang SH
• Park JA
• Jang YS
• Lee KM
• Lee DS
• Ahn BM
• Lee EH

Abstract

The potential hepatotoxicity of herbal remedies is usually ignored in daily life. One such compound, Boh-Gol-Zhee (in Chinese, Bu Ku Zi), appeared to be the cause for acute cholestatic hepatic injury in the following case. Psoralea corylifolia is known to contain a sufficient amount of phyto-estrogen. Some alternative medicine therapists claim that Psoralea corylifolia is effective for the treatment of osteoporosis. So far, at least 35 chemical components in the fruits of Psoralea corylifolia have been identified. High concentrations of phyto-estrogen, such as genistein, have been found in the leaves of Psoralea corylifolia. Phyto-estrogen has structural similarity to estrogen and exhibits beneficial effects on osteoporosis under estrogen-deficient conditions. The authors observed a case of acute cholestatic hepatitis in a post-menopausal woman caused by seeds of Psoralea corylifolia in amounts over 10 times the usual dose. Other possible causes of liver injury were excluded by laboratory tests and imaging studies. After discontinuation of this remedy, elevated liver enzyme and total bilirubin rapidly returned to normal. Liver biopsy showed zone 3 necrosis, degenerating cells, cholestasis and infiltrations with inflammatory cells. This case stresses the need to warn the potential hepatotoxicity of Psoralea corylifolia seeds, especially in a large dose.

Keyword

Acute cholestatic hepatitis; Psoralea corylifolia; Phyto-estrogen

MeSH Terms

Asian Continental Ancestry Group
Bilirubin
Biopsy
Cholestasis
Complementary Therapies
Estrogens
Female
Fruit
Genistein
Hepatitis*
Humans
Liver
Necrosis
Osteoporosis
Phytoestrogens
Psoralea
Bilirubin
Estrogens
Genistein
Phytoestrogens