Pediatr Allergy Respir Dis.  2006 Mar;16(1):38-46.

Investigation of the Influence of Low Birth Weight on the Severity of Asthma in Prealdolescent Children and Aldolescence

• Jeung H
• Kim HD
• Lee YJ
• Lee KW

Abstract

PURPOSE: Over the past several decades, the survival rates of low birth weight(LBW; birth weight <2,500 g) infants have been improving. Many of these infants have had bronchial asthma(BA) at childhood and aldolescence. The aim of this study is to investigate whether LBW influenced the severity of BA in prealdolescent children and aldolescence by a retrospective case control study.
METHODS
15 LBW children(1,500 gRESULTS
LBW group had:a significantly more severe symptoms between 8 year-old and 18 year-old than control group.(P=0.015) A significantly more used to ICSs(Inhaled corticosteroids) and add-on therapy than control group.(P=0.009)(P=0.0001) There were no significant differences in the PFT and PC20 and specific IgE Ab. between LBW group and control group. But, total IgE level is higher in the control group than in the LBW group.
CONCLUSION
These results suggest that LBW is a risk factor for the severity of BA. We suggest that infants with birth weight of less than 2,500 g have a more severe risk of asthma during prealdolescent children and aldolescence than who were birth weight of more than 2,500 g.

Keyword

Low birth weight infant; Bronchial asthma

MeSH Terms

Adolescent
Asthma*
Birth Weight
Case-Control Studies
Child*
Humans
Hypersensitivity
Immunoglobulin E
Infant
Infant, Low Birth Weight*
Infant, Newborn
Methacholine Chloride
Parturition
Reference Values
Retrospective Studies
Risk Factors
Survival Rate
Immunoglobulin E
Methacholine Chloride