Korean J Psychosom Med.  2013 Dec;21(2):81-92.

Adverse Effect of Newer Antidepressant ; Nausea and Vomiting, Weight Gain, Sexual Dysfunction: Mechanisms, Epidemiology, and Pharmacological Management

• Lee KK

Abstract

Newer antidepressants are commonly used in clinical practice to treat psychiatric disorder and psychosomatic disorder including chronic pain syndrome, fibromyalgia, headache. However there are many unexpected adverse effects of these drugs such as nausea and vomiting, weight gain, sexual dysfunction. These are 3 most well-recognized common adverse effects of newer antidepressant and are most common causes of treatment failure. I reviewed mechanisms, epidemiology, and pharmacological management of these adverse effects of newer antidepressants. In this paper, newer antidepressants include selective serotonin reuptake inhibitor(fluoxetine, fluvoxamine, citalopram, escitalopram, sertraline, paroxetine), serotonin norepinephrine reuptake inhibitor(venlafaxine, duloxetine), norepinephrine and dopamine reuptake inhibitor(bupropion), noradrenergic and specific serotonergic antidepressant(mirtazapine), and reversible inhibitor of MAO-A(moclobemide). I suggest that psychiatrists and clinicians in the psychosomatic field should know mechanisms, epidemiology, and management of these common and well-recognized adverse effects of newer antidepressants. Therefore it will be helpful to recognize easily and treat well for patients with psychiatric disorder and psychosomatic disorder using newer antidepressants.

Keyword

Newer antidepressant; Nausea and vomiting; Weight gain; Sexual dysfunction

MeSH Terms

Antidepressive Agents
Chronic Pain
Citalopram
Dopamine
Epidemiology*
Fibromyalgia
Fluvoxamine
Headache
Humans
Nausea*
Norepinephrine
Psychiatry
Psychophysiologic Disorders
Serotonin
Sertraline
Treatment Failure
Vomiting*
Weight Gain*
Antidepressive Agents
Citalopram
Dopamine
Fluvoxamine
Norepinephrine
Serotonin
Sertraline