J Korean Med Assoc.  2007 Jan;50(1):65-70. 10.5124/jkma.2007.50.1.65.

Prevention and Treatment of Postoperative Nausea and Vomiting

• Lee HY
• Park H

• KMID: 2184796
• DOI: http://doi.org/10.5124/jkma.2007.50.1.65

Abstract

Postoperative nausea and vomiting is an adverse condition that affects a large number of patients after surgical interventions. Postoperative vomiting is a severe discomfort for patients and can be a bigger concern even than postoperative pain. Although many studies have been performed on the pathophysiology of postoperative nausea and vomiting, little has been known about it. This article reviews the risk factors, mechanisms, preventive measures, and treatment of postoperative nausea and vomiting.

Keyword

Postoperative nausea and vomiting

MeSH Terms

Humans
Pain, Postoperative
Postoperative Nausea and Vomiting*
Risk Factors

Figure

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  Figure 1 Hypothetical model of the pathophysiology of postoperative nausea and vomiting(5)

Reference

1. Apfel CC, Roewer N, Krier C, Noldge-Schomburg G. Postoperative nausea and vomiting: improved understanding and better strategies Part I. Anasthesiol. Intensivmed. Notfallmed. Schmerzther. 2004. 39:490–501.

2. Kovac AL. Prevention and treatment of postoperative nausea and vomiting. Drugs. 2000. 59:213–243.

3. Gold BS, Kitz DS, Lecky JH, Neuhaus JM. Unanticipated admission to the hospital following ambulatory surgery. JAMA. 1989. 262:3003–3010.

4. Livingston EH, Passaro EP. Postoperative ileus. Dig Dis Sci. 1990. 35:121–132.

5. Kreis ME. Postoperative nausea and vomiting. Autonomic Neuroscience: Basic and Clinica. 2006.

6. Belyansky LS, Sayenko VF, Furmanov JA, Churilova TJ. Bacterial translocation as a cause for septic complications in obstructive colonic ileus. Acta Chir Belg. 2002. 102:75–77.

7. Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I, Zernak C, Danner K, Jokela R, Pocock SJ, Trenkler S, Kredel M, Biedler A, Sessler DI, Roewer N. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med. 2004. 350:2441–2451.

8. Palazzo MGA, Strunin L. Anaesthesia and emesis. I: etiology. Can Anaesth Soc J. 1984. 31:178–187.

9. Patel RI, Hanallah RS. Anesthetic complications following pediatric ambulatory surgery: a 3-year study. Anesthesiology. 1988. 69:1009–1012.

10. Larsson S, Jonmarker C. Postoperative emesis after pediatric strabismus surgery: the effect of dixyrazine compared to droperidol. Acta Anaesthesiol Scand. 1990. 34:227–230.

11. Hillsley K, Eeckhout C, Grundy D. Cilansetron acts at its site of absorption to antagonize the sensitivity of mesenteric afferent fibres to 5-hydroxytryptamine in the rat jejunum. Neurosci Lett. 2000. 278:137–140.

12. Henzi I, Walder B, Tramer MR. Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg. 2000. 90:186–194.

13. Tramèr MR. A rational approach to the control of postoperative nausea and vomiting. Evidence from systematic reviews. Part II. Recommendations for prevention and treatment, and research agenda. Acta Anaesthesiol Scand. 2001. 45:14–19.

14. Pierre S. Apfel's simplified score may favourably predict the risk of postoperative nausea and vomiting. Can J Anaesth. 2002. 49:237–242.

15. Apfel CC, Laara F, Koivuranta M, Greim CA, Roewer N. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology. 1999. 91:693–700.

16. Apfel CC, Kranke P, Katz MH, Goepfert C, Papenfuss T, Roewer N. Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design. Br J Anaesth. 2002. 88:234–240.

17. Henzi I, Walder B, Tramèr MR. Metoclopramide in the prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized, placebocontrolled studies. Anaesthesia. 2002. 57:1022–1027.