Korean J Pediatr.  2004 Aug;47(8):904-907.

A Case of Kikuchi-Fujimoto Disease, Subsequently Evolving to Systemic Lupus Eyrthematosus

• Yoon SH
• Song MH
• Shin SH
• Kim SK
• Lee KH
• Yoon HS
• Jung YO
• Ahn HK

Abstract

Kikuchi-Fujimoto disease(KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limited systemic illness and it has the pathognomonic histological appearance of lymph nodes. KFD is rarely associated with systemic lupus erythematosus (SLE). The diagnosis of KFD can precede, postdate or coincide with the diagnosis of SLE. Our case describes a young woman, originally diagnosed as having Kikuchi's disease by lymph node histology, who subsequently developed SLE with constitutional symptoms, skin rash, hematologic and immunologic disorder and high titer of antinuclear antibody. This raises consideration for the proposal that KFD may reflect a SLE-like auto-immune condition. Patients with KFD should be kept under observation for several years for the development of SLE. And KFD should be ruled out in SLE flare-up accompanied by lymphadenopathy.

Keyword

Kikuchi-Fujimoto disease; Histiocytic necrotizing lymphadenitis; Systemic lupus erythematosus

MeSH Terms

Antibodies, Antinuclear
Diagnosis
Exanthema
Female
Histiocytic Necrotizing Lymphadenitis*
Humans
Lupus Erythematosus, Systemic
Lymph Nodes
Lymphatic Diseases
Antibodies, Antinuclear