Korean J Pathol.  2014 Feb;48(1):43-49.

Uncommon and Rare Human Papillomavirus Genotypes Relating to Cervical Carcinomas

• Kim NR
• Kang M
• Lee SP
• Kim H
• An J
• Chung DH
• Ha SY
• Cho HY

Abstract

BACKGROUND
Human papillomavirus (HPV) is an oncogenic virus in cervical cancer and most invasive carcinomas (ICs) are caused by HPV16 and 18. However, the roles and contributions of other uncommon and rare genotypes remain uncertain.
METHODS
HPV genotypes were retrospectively assessed using an HPV DNA chip that can specify up to 32 HPV genotypes. We arbitrarily regarded genotypes accounting for less than 6% of the total as uncommon and rare genotypes.
RESULTS
A total of 3,164 HPV-positive cases were enrolled. In groups 2A, 2B, 3, and unclassified HPV genotypes, 2.4% of cases with uncommon HPV genotypes (68, 26, 34, 53, 66, 69, 70, 73, 40, 42, 43, 44, 54, 55, 61, 62, 6, and 11) showed high grade squamous intraepithelial lesions and ICs. There were no HPV32- and 57-infected cases.
CONCLUSIONS
We found that the uncommon and rare HPV genotypes may provide incremental etiologic contributions in cervical carcinogenesis, especially HPV68, 70, and 53. Further studies on these uncommon and rare HPV genotypes will be of importance in establishing the significance of genotypes in different regions, especially in planning a strategy for further vaccine development as well as follow-up on the effectiveness of the currently used vaccines.

Keyword

Human papillomavirus; Cervix uteri; Carcinogenesis; Genotype

MeSH Terms

Carcinogenesis
Cervix Uteri
Female
Follow-Up Studies
Genotype*
Humans*
Oligonucleotide Array Sequence Analysis
Oncogenic Viruses
Retrospective Studies
Uterine Cervical Neoplasms
Vaccines
Vaccines