Korean J Gastroenterol.
2002 Dec;40(6):402-405.
A Case of Colon Cancer in a Patient with Neurofibromatosis Type I
- Affiliations
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- 1Department of Internal Medicine, Dong-A University, College of Medicine, Pusan, Korea. seokca@hanmail.net
Abstract
- Neurofibromatosis type I is an autosomal dominant disorder that occurs once in 3,000 births. It is characterized by neurofibromas and caf au lait spots of the skin. Neurofibromatosis type I gene is a tumor suppressor gene. Patients with neurofibromatosis type I are at an increased risk of developing neural neoplasms including optic glioma, astrocytoma, acoustic neuroma, neurilemmoma, and meningioma. The patients with neurofibromatosis type I showed high incidence of Wilm's tumor, rhabdomyosarcoma, leukemia, and pheochromocytoma but rare incidence of colon cancer. We experienced a case of sigmoid colon cancer and multiple adenomatous polyps of the colon in a patient with sporadic neurofibromatosis type I.
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