Korean J Clin Neurophysiol.  2013 Dec;15(2):63-67. 10.14253/kjcn.2013.15.2.63.

Multiple Cranial Neuropathy with and Polyradiculoneuropathy as a Delayed Sequelae after of Ethylene Glycol Intoxication

• Kim MS
• Kim SY
• Kwon JH
• Kim WJ
• Jung HC

• KMID: 1863276
• DOI: http://doi.org/10.14253/kjcn.2013.15.2.63

Abstract

Multiple cranial and peripheral neuropathies as a delayed sequellae of ethylene glycol poisoning is a less well known clinical entity and its information about long-term electrophysiological and clinical outcomes is limited. We report a 45-year-old male who presented with acute renal failure and subsequently developed multiple cranial neuropathy, respiratory failure, and flaccid tetraparesis. Through sequential electrophysiological studies, we would like suggest that the main pathophysiology of ethylene glycol-related neuropathy is a demyelinating polyradiculoneuropathy with secondary axonal degeneration.

Keyword

Ethylene glycol; Multiple cranial neuropathy; Polyneuropathy

MeSH Terms

Acute Kidney Injury
Axons
Cranial Nerve Diseases*
Ethylene Glycol*
Humans
Male
Middle Aged
Peripheral Nervous System Diseases
Poisoning
Polyneuropathies
Polyradiculoneuropathy*
Respiratory Insufficiency
Ethylene Glycol

Figure

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  Figure 1. Serial motor-conduction study findings for the peroneal and tibial nerves in the patient. (A, C) Conduction block is present between the ankle and knee. (B, D) Follow-up study suggested a secondary axonal degeneration.

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