Korean Circ J.  2006 Aug;36(8):600-604. 10.4070/kcj.2006.36.8.600.

Comparisons of the Short-Term Angiographic Outcomes of Cypher and Taxus Stents Implanted in the Same Patient

• Park MA
• Ryu JN
• Lim TH
• Yoo HS
• Yoon HA
• Koo JM
• Lee SE
• Paik JH
• Kim KH
• Han J
• Park TH
• Cha KS
• Kim MH
• Kim YD

• KMID: 1859069
• DOI: http://doi.org/10.4070/kcj.2006.36.8.600

Abstract

BACKGROUND AND OBJECTIVES: Drug-eluting stents (DES) have been shown to substantially reduce both angiographic and clinical restenosis. Cypher(R) (sirolimus-eluting stent, Cordis, Johnson and Johnson, Florida, USA) and Taxus(R) (paclitaxel-eluting stent, Boston Scientific, Boston, USA) are the two most widely used DESs, and they both have distinct pharmacological properties and release kinetics. It has been not studied whether these two DESs show different angiographic outcomes when they are simultaneously implanted in the same patient.
SUBJECTS AND METHODS
We retrospectively analyzed the angiographic findings of the short-term follow-up in 34 patients (average age: 63 year old, 9 women) in whom both Cypher and Taxus stents were implanted at the same time for the treatment of obstructive coronary lesion.
RESULTS
There was no significant difference in the basal angiographic characteristics of the lesions that had two stents deployed in terms of the AHA/ACC classification, reference diameter, the percent diameter stenosis and minimal luminal diameter. The post-procedure results were similar between the two stents. At 6 months follow-up, the Cypher stent displayed significantly less in-stent lumen loss compared with the Taxus stent (0.16+/-0.04 mm vs 0.27+/-0.04 mm; respectively, p=0.040) and a smaller percent diameter stenosis (15.9+/-1.3% vs 19.9+/-2.2%, respectively, p=0.049).
CONCLUSION
The Cypher stent showed significantly less luminal loss during short term follow-up compared with the Taxus stent when implanted in the same patient. This result suggests that in a given individual patient, the Cypher stent induces less neointimal proliferation than does the Taxus stent.

Keyword

Sirolimus; Paclitaxel; Coronary restenosis

MeSH Terms

Classification
Constriction, Pathologic
Coronary Restenosis
Drug-Eluting Stents
Florida
Follow-Up Studies
Humans
Kinetics
Middle Aged
Paclitaxel
Phenobarbital
Retrospective Studies
Sirolimus
Stents*
Taxus*
Paclitaxel
Phenobarbital
Sirolimus