Korean J Intern Med.  2013 Jan;28(1):72-80. 10.3904/kjim.2013.28.1.72.

Clinical outcomes between different stent designs with the same polymer and drug: comparison between the Taxus Express and Taxus Liberte stents

• Son JW
• Kim U
• Park JS
• Kim YJ
• Jang JS
• Yang TH
• Kim DS
• Kim DK
• Seol SH
• Kim DI
• Nam CW
• Hur SH
• Kim KB

• KMID: 1793221
• DOI: http://doi.org/10.3904/kjim.2013.28.1.72

Abstract

BACKGROUND/AIMS
The Taxus Liberte stent (Boston Scientific Co.) evolved from the Taxus Express stent, with enhanced stent deliverability and uniform drug delivery. This study was designed to compare angiographic and clinical outcomes in real-world practice between the Taxus Liberte and Taxus Express stents.
METHODS
Between 2006 and 2008, 240 patients receiving the Taxus Liberte stent at three centers were registered and compared to historical control patients who had received the Taxus Express stent (n = 272). After propensity score matching, 173 patients treated with the Taxus Liberte stent and the same number of patients treated with the Taxus Express stent were selected. The primary outcome was a composite of major adverse cardiac events (MACE), including cardiac death, myocardial infarction (MI), ischemia driven target vessel revascularization (TVR), and stent thrombosis (ST) at 1 year. An additional angiographic assessment was conducted at 9 to 12 months.
RESULTS
The study showed no significant difference between the Taxus Express and Taxus Liberte stents (death, 1.73% vs. 2.31%, p = 1.000; MI, 0% vs. 1.73%, p = 0.2478; TVR, 2.31% vs. 1.16%, p = 0.6848; and ST, 0% vs. 1.16%, p = 0.4986). The total MACE rate at 1 year did not differ between the groups (4.05% in Taxus Express vs. 4.05% in Taxus Liberte, p = 1.000). In addition, the binary restenosis rate did not differ (2.25% in Taxus Express vs. 1.80% in Taxus Liberte, p = 0.6848).
CONCLUSIONS
In real-world experience with the two Taxus stent designs, both stents showed similarly good clinical and angiographic outcomes at 1 year. A long-term follow-up study is warranted.

Keyword

Angioplasty; Drug-eluting stents; Polymers

MeSH Terms

Aged
Angioplasty, Balloon, Coronary/adverse effects/*instrumentation/mortality
Cardiovascular Agents/administration & dosage
Chi-Square Distribution
Coronary Angiography
Coronary Artery Disease/mortality/radiography/*therapy
Coronary Restenosis/etiology/mortality
Coronary Thrombosis/etiology/mortality
*Drug-Eluting Stents
Female
Humans
Male
Middle Aged
Myocardial Infarction/etiology/mortality
Paclitaxel/*administration & dosage
Propensity Score
Prosthesis Design
Registries
Republic of Korea
Retrospective Studies
Risk Factors
Stainless Steel
Time Factors
Treatment Outcome
Cardiovascular Agents
Stainless Steel
Paclitaxel