Korean Circ J.  2003 Aug;33(8):695-700. 10.4070/kcj.2003.33.8.695.

Usefulness of B-type Natriuretic Peptide in Congestive Heart Failure

• Kwon SH
• On YK
• Han DH
• Lee SC
• Jo YH
• Lee NH
• Hyun MS
• Kim SK
• Kwon YJ

• KMID: 1858777
• DOI: http://doi.org/10.4070/kcj.2003.33.8.695

Abstract

BACKGROUND AND OBJECTIVES
B-type natriuretic peptide (BNP) is released from the cardiac ventricles in response to increased wall tension. Early diagnosis of congestive heart failure (CHF) and assessment of the left ventricular end diastolic pressure (LVEDP) are thought to be important in the diagnosis, treatment and follow up of patients with CHF.
SUBJECTS AND METHODS
Between March, 2002 and November, 2002, 50 patients, who were admitted for treatment and hemodynamic monitoring, were studied. For the BNP measurement, 3 to 5ml blood samples were collected into tubes containing EDTA. The BNP was measured with a fluorescence immunoassay kit (Triage, Biosite, San Diego, U.S.A.). Cardiac Catheterization was performed for the assessment of the LVEDP.
RESULTS
Of the 50 subjects, 34 with CHF had a mean BNP level of 483.1+/-77.8 pg/mL, whereas those without CHF had a level of 79.2+/-24.0 pg/mL. The difference between the groups was statistically significant (p=0.005). A significant positive correlation was seen between the BNP and the LVEDP (r=0.53, p=0.001). The correlation between the BNP and the left ventricular ejection fraction (LVEF) was not statistically significant (r=-0.226, p=0.198).
CONCLUSION
The plasma BNP was significantly increased in CHF, and might reflect the LVEDP. Further study will be required to see whether the BNP is a useful parameter for the staging and treatment of CHF.

Keyword

Natriuretic peptide, brain; Ventricular pressure; Heart failure, congestive

MeSH Terms

Blood Pressure
Cardiac Catheterization
Cardiac Catheters
Diagnosis
Early Diagnosis
Edetic Acid
Estrogens, Conjugated (USP)*
Fluorescence
Follow-Up Studies
Heart Failure*
Heart Ventricles
Hemodynamics
Humans
Immunoassay
Natriuretic Peptide, Brain*
Plasma
Stroke Volume
Ventricular Pressure
Edetic Acid
Estrogens, Conjugated (USP)
Natriuretic Peptide, Brain