Korean Circ J.  2002 Jun;32(6):479-484. 10.4070/kcj.2002.32.6.479.

The Effects of (66)Ho-Loaded Radioactive Stent in a Porcine Model

• Lee DC
• Jeong MH
• Kim KH
• Lee HS
• Bom HS
• Hong YD
• Choi SJ
• Park KB
• Kim EH
• Cho JG
• Park JC
• Kang JC

• KMID: 1858671
• DOI: http://doi.org/10.4070/kcj.2002.32.6.479

Abstract

BACKGROUND AND OBJECTIVES: Vascular brachytherpy known to be an effective method in the prevention of restenosis following percutaneous coronary intervention (PCI). In this study we observed the effects of a radioisotope-loaded stent in a porcine model.
MATERIALS AND METHODS
Holmium-166 ((166)Ho) was loaded onto the stent surface using impregnated polyurethane, and placed the stents into 7 porcine coronary arteries. Four weeks after stent overdilation injury, histopathological examination was performed.
RESULTS
The absorbed dose of (166)Ho to the coronary artery, from the 158.5+/-140.9 microCi (166)Ho stent, was about 141 Gy at a depth of 0.5 mm, which was calculated by Monte Carlo EGS 4 Code. The mean external, and internal elastic lamina areas, the luminal and neointimal areas and the histopathological area stenosis in the 7 porcine coronary arteries were 7.6+/-2.8 mm2, 4.7+/-1.6 mm2, 2.4+/-1.4 mm2, 2.3+/-1.6 mm2 and 49.4+/-24.9%, respectively. The histopathological findings revealed remarkable inflammatory reactions and thrombosis in two of the porcine coronary arteries.
CONCLUSION
(166)Ho radioactive loaded stents, using impregnated polyurethane, may inhibit neointimal hyperplasia, but the problems of stent thrombosis and inflammation should be solved.

Keyword

Coronary restenosis; Stents; Thrombosis; Radioisotopes

MeSH Terms

Constriction, Pathologic
Coronary Restenosis
Coronary Vessels
Hyperplasia
Inflammation
Percutaneous Coronary Intervention
Phenobarbital
Polyurethanes
Radioisotopes
Stents*
Thrombosis
Phenobarbital
Polyurethanes
Radioisotopes