Korean Circ J.  2000 Sep;30(9):1139-1148. 10.4070/kcj.2000.30.9.1139.

The Effects of Local Radiation using Ho-166 Balloon on Porcine Coronary Restenosis

• Lee SW

• KMID: 2093757
• DOI: http://doi.org/10.4070/kcj.2000.30.9.1139

Abstract

BACKGROUND: Restenosis remains one of major clinical problems in the coronary intervention. The effects of local radiation using radioactive balloon loaded with Ho-166 on coronary restenosis in the porcine model were observed.
METHODS
Overdilation injury was performed in porcine coronary arteries using control balloon [Group I, n=, left anterior descending artery (LAD)=, left circumflex artery (LCX)=, right coronary artery (RCA)=] and Ho-166 loaded polyurethane-coating balloon [Group II; n=0, 21.98.1 mCi (20 Gy at 0.5 mm in depth), LAD=, LCX=, RCA=] at 5 atm for 3 min. Follow-up quantitative coronary angiogram (QCA) and histopathologic findings were compared at 4 weeks after balloon injury between two groups.
RESULTS
Acute or late thrombotic arterial occlusion was not observed in both groups. Diameter stenosis measured by QCA was not different between two groups (Group I: 11.61.6%, II: 7.68.4%, P=.44). On histopathologic study, injury score, external and internal elastic lamina area, and media area were not different between two groups. Neointimal area and histopathologic area stenosis were significantly higher in Group I (0.320.86mm2, 20.677.01%) than those of Group II (0.150.26mm2, 12.032.44%). By immunocytochemistry, proliferating cell nuclear antigen indices in neointima and media were 8.244.44%, 7.972.46% in Group I, and 7.172.25%, 5.471.44% in Group II, which were not different between two groups(P=.587, 0.089).
CONCLUSION
Local radiation using Ho-166 balloon is effective in reducing neointimal proliferation in a porcine model.

MeSH Terms

Arteries
Constriction, Pathologic
Coronary Restenosis*
Coronary Vessels
Follow-Up Studies
Immunohistochemistry
Neointima
Proliferating Cell Nuclear Antigen
Proliferating Cell Nuclear Antigen