Pediatr Allergy Respir Dis.  1999 Jun;9(2):210-218.

A Comparison of Concentrations of TNF-alpha and IFN-gamma between the Dose of Intravenous Immunoglobulin 1 gm/kg and 2 gm/kg in the Patients with Kawasaki Disease

• Kim BS
• Shim JY
• Park KH
• Kim YH
• Hong SJ

Abstract

PURPOSE
Recently, the protocol of high dose of intravenous immunoglobulin has been preferred in the treatment of acute stage of Kawasaki disease. In this study, we have compared the serum concentrations of TNF-alpha and IFN-gamma in the patients with Kawasaki disease between intravenous immunoglobulin of 1 gm/kg and 2 gm/kg groups.
METHODS
Fourteen patients admitted to Asan Medical Center were enrolled in this study. These patients met the diagnostic criteria of Kawasaki disease divided into two groups by the dose of intravenous immunoglobulin, 1 gm/kg and 2 gm/kg. The concentrations of TNF-alpha and IFN-gamma using ELISA methods were measured before and after the 5th and 14th days of intravenous immunoglobulin.
RESULTS
The serum levels of TNF-alpha and IFN-gamma showed no statistically significant difference between 1 gm/kg and 2 gm/kg group of intravenous immunoglobulin on before the treatment and the 5th, 14th days after the infusion of intravenous immunoglobulin.
CONCLUSION
There is no difference of serum concentrations of TNF-alpha and IFN-gamma between the intravenous immunoglobulin of 1 gm/kg and 2 gm/kg doses in an acute stage of Kawasaki disease. The dose of immunoglobulin in a treatment of Kawasaki disease needs to be examined in future studies.

Keyword

Kawasaki disease; Intravenous immunoglobulin; Tumor necrosis factor-alpha; Interferon-gamma

MeSH Terms

Chungcheongnam-do
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulins*
Interferon-gamma
Mucocutaneous Lymph Node Syndrome*
Tumor Necrosis Factor-alpha*
Immunoglobulins
Interferon-gamma
Tumor Necrosis Factor-alpha