J Korean Radiol Soc.  2008 Mar;58(3):313-320. 10.3348/jkrs.2008.58.3.313.

Diagnostic Value of Dynamic Perfusion MR Imaging in Benign and Malignant Musculoskeletal Lesions

• Choi BK
• Lee SH
• Cha JH
• Kim SM
• Shin MJ
• Han H
• Kim SS
• Lee JY
• Jeon YH

• KMID: 1852947
• DOI: http://doi.org/10.3348/jkrs.2008.58.3.313

Abstract

PURPOSE
To assess the diagnostic value of dynamic perfusion MR imaging for differentiation between benign and malignant musculoskeletal lesions.
MATERIALS AND METHODS
Dynamic perfusion MR imaging was performed using a 3.0 T system in 32 female and 30 male patients (aged 10-90 years, mean age, 43 years). Following the assessment of the precontrast imaging, a dynamic study was performed. This dynamic technique allowed for 638 images to be obtained at 11 levels throughout the lesion. Twenty-eight lesions originated within bone (8 benign, 20 malignant), whereas 34 lesions were of soft tissue origin (22 benign, 12 malignant). The final diagnosis was histopathologically confirmed in all patients. To differentiate between benign and malignant lesions, we analyzed the four parameters: (maximal relative enhancement (MRE), time to peak (TTP), wash in rate (WI), steepest slope (SS) and the distribution of time intensity curve (TIC) patterns.
RESULTS
The TTP, WI, and SS values of malignant lesions were statistically significant from those of benign lesions (p < 0.05). However, the difference for the MRE values was not statistically significant. The distribution of TIC patterns was a helpful indicator of benign or malignant state, however the difference between the two states was not significant.
CONCLUSION
Dynamic perfusion MR imaging is a helpful tool in differentiating benign and malignant musculoskeletal lesions.

Keyword

Magnetic resonance (MR); Bone neoplasms; Soft tissue neoplasms; Musculoskeletal diseases

MeSH Terms

Bone Neoplasms
Female
Humans
Male
Musculoskeletal Diseases
Perfusion
Soft Tissue Neoplasms
Thymine Nucleotides
Tics
Thymine Nucleotides