J Korean Acad Rehabil Med.  2007 Jun;31(3):375-379.

Multiorgan Thrombotic Occlusions after Acitretin Treatment in a Patient with Chronic Psoriasis: A case report

• Yang CY
• Kim TJ
• No SE
• Joo MC
• Kil EY
• Shin YI

Abstract

Psoriasis, whose symptom is shown in around 1~3% American people, is a chronic and inflammatory skin disease. There are many treatments for pustular and erythrodermic psoriasis and oral retinoid which is a synthetic derivative of vitamin A is the most popular drug of them. Acitretin called as the second generation retinoid is a kind of active retinoid metabolite, which shows some drug toxicities in hepatic, skeletal and cardiovascular systems including atherosclerosis after a long term use. Even though that, we have just one case which has ever reported on acitretin-associated thrombotic stroke so far. We report a case on a patient who has multiorgan thrombotic occlusions resulted from longstanding psoriatic treatments by using acitretin for five years. This patient suffers from lots of complications such as superior mesenteric artery thrombosis, small cerebellar infarctions, cerebral infarction, acute renal failure concomitant with both small renal infarctions and atherosclerosis obliterans in his two legs.

Keyword

Acitretin; Thrombosis; Psoriasis

MeSH Terms

Acitretin*
Acute Kidney Injury
Atherosclerosis
Cardiovascular System
Cerebral Infarction
Drug-Related Side Effects and Adverse Reactions
Humans
Infarction
Leg
Mesenteric Artery, Superior
Psoriasis*
Skin Diseases
Stroke
Thrombosis
Vitamin A
Acitretin
Vitamin A