Tuberc Respir Dis.  2009 Mar;66(3):186-191. 10.4046/trd.2009.66.3.186.

Prevalence and Risk Factors of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease

• Sim YS
• Lee JH
• Ryu YJ
• Chun EM
• Chang JH

• KMID: 1846378
• DOI: http://doi.org/10.4046/trd.2009.66.3.186

Abstract

BACKGROUND: Osteoporosis is a significant comorbidity in patients with chronic obstructive pulmonary disease (COPD). This study examined the prevalence and risk factors associated with osteoporosis in patients with COPD.
METHODS
The bone mineral densities (BMDs) of the lumbar spine and femoral bone were measured in 53 patients with clinically stable COPD and 41 age- and gender-matched control subjects showing a normal lung function. Osteoporosis was defined as a T-score < or =-2.5. The subjects' clinical characteristics and laboratory data were reviewed, and multiple logistic regression analysis was used to identify the risk factors associated with osteoporosis in COPD patients.
RESULTS
The prevalence of osteoporosis was 47% and 32% in the COPD patients and controls, respectively. In particular, using the femoral neck T-score, the prevalence of osteoporosis in COPD patients was higher than that in the controls (26% vs. 5%; p=0.006). The average T-score of the lumbar spine (p=0.025) and femoral neck of COPD patients were significantly lower than those of the controls (p=0.001). The forced expiratory volume in the 1 second (FEV1) % predicted (p=0.019; odds ratio [OR], 0.955; 95% confidence interval [CI], 0.919-0.993) and age (p=0.024; OR, 1.144; 95% CI, 1.018-1.287) were independently associated with osteoporosis in patients with COPD.
CONCLUSION
Using the femoral neck T-score, the prevalence of osteoporosis in patients with COPD was higher than the age-and gender-matched controls. A lower FEV1 and older age further increase the risk of osteoporosis in patients with COPD.

Keyword

Chronic obstructive pulmonary disease; Osteoporosis; Prevalence; Risk factor; Lung function

MeSH Terms

Bone Density
Comorbidity
Femur Neck
Forced Expiratory Volume
Humans
Logistic Models
Lung
Odds Ratio
Osteoporosis
Prevalence
Pulmonary Disease, Chronic Obstructive
Risk Factors
Spine

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