Korean J Med.  2013 Mar;84(3):360-362. 10.3904/kjm.2013.84.3.360.

Non-Alcoholic Fatty Liver Disease and Colonic Neoplasm

• Kim JW
• Byeon JS

• KMID: 1833844
• DOI: http://doi.org/10.3904/kjm.2013.84.3.360

Abstract

The incidence of colorectal neoplasm including adenomas and carcinomas is increasing in Korea. It has been reported that certain components of the metabolic syndrome including abdominal obesity and abnormal glucose metabolism are associated with increased risk for colorectal cancer. The mechanism involved is most likely linked to metabolic stress, which is associated with increased levels of insulin-like growth factor-1 and TNF-alpha, which promote cell proliferation and survival. Non-alcoholic fatty liver disease (NAFLD) is commonly referred to as the hepatic manifestation of the metabolic syndrome. The study by Lee et al. showed that NAFLD is associated with increased risk for colonic neoplasm. Further studies are needed to decide whether patients with NAFLD require a screening colonoscopy at a younger age than currently recommended.

Keyword

Non-alcoholic fatty liver disease; Colorectal neoplasm; Metabolic syndrome

MeSH Terms

Adenoma
Cell Proliferation
Colon
Colonic Neoplasms
Colonoscopy
Colorectal Neoplasms
Fatty Liver
Glucose
Humans
Incidence
Korea
Mass Screening
Obesity, Abdominal
Stress, Physiological
Tumor Necrosis Factor-alpha
Fatty Liver
Glucose
Tumor Necrosis Factor-alpha