Korean J Med.  2005 Jun;68(6):697-703.

Successful treatment of Staphylococcus aureus associated rapid progressive glomerulonephritis and pulmonary hemorrhage with plasmapheresis

• Ye YM
• Lee SW
• Oh YJ
• Sheen SS
• Choi YH
• Hwang SC
• Yim HE

Abstract

A 45-year-old man was admitted for fever, myalgia, and generalized edema with multiple localized erythema. He had no healthy problem before these symptoms developed. Abdominal CT scan showed multiple abscess in the right buttock, left psoas, and both inguinal area. Blood and wound culture drawn during the hospitalization grew methicillin sensitive Staphylococcus aureus (MSSA). Although antibiotic therapy and incisional drainage of abscess pocket, acute renal insufficiency was progressed and massive pulmonary hemorrhage and acute respiratory failure were developed. In addition to antibiotics, plasmapheresis and steroid pulse therapy made him improved dramatically from acute renal failure and pulmonary hemorrhage. The renal biopsy showed pauci-immune crescentic glomerulonephritis (GN). This result supports that plasmapheresis and steroid therapy may be beneficial in the treatment of staphylococcal infection-associated GN as several groups reported.

Keyword

Glomerulonephritis; Staphylococcus aureus; Plasmapheresis

MeSH Terms

Abscess
Acute Kidney Injury
Anti-Bacterial Agents
Biopsy
Buttocks
Drainage
Edema
Erythema
Fever
Glomerulonephritis*
Hemorrhage*
Hospitalization
Humans
Methicillin
Middle Aged
Myalgia
Plasmapheresis*
Respiratory Insufficiency
Staphylococcus aureus*
Staphylococcus*
Tomography, X-Ray Computed
Wounds and Injuries
Anti-Bacterial Agents
Methicillin