J Korean Radiol Soc.  1995 Nov;33(5):793-796.

Paroxysmal Nocturnal Hemoglobinuria: A Case Report of MR, CT Findings

• Yang I
• Chun RW
• Lee Y
• Chung SY
• Park HJ
• Noh JW

Abstract

Paroxysmal nocturnal hemoglobinuria(PNH) is a rare, acquired disease involving multiple hematopoietic lines. Characteristics of PNH are intrinsic hemolytic anemia, iron deficiency anemia and venous thrombosis. report a case of PNH with characterostoc MR and CT findings. The signal intensity of renal cortex was lower than that of medulla on both T1- and T2- weighted MR imaging. On T2 weighted MR images, the liver showed very low signal intensity but the signal intensity of the spleen was normal. On precontrast CT the attenuation of renal cortex was higher than that of renal medulla and the attenuation of liver was higher than that of the spleen. These findings of MR imaging and CT were the result from the deposition of hemosiderin in the cells of proximal convoluted tubules and transfusional hemosiderosis of liver.

MeSH Terms

Anemia, Hemolytic
Anemia, Iron-Deficiency
Hemoglobinuria, Paroxysmal*
Hemosiderin
Hemosiderosis
Liver
Magnetic Resonance Imaging
Spleen
Venous Thrombosis
Hemosiderin