J Korean Epilepsy Soc.  2006 Jun;10(1):56-59.

A Case of Reversible Peripheral Neuropathy Caused by Chronic Phenytoin Intoxication

• Han YS
• Cho JS
• Park SE
• Kim JM
• Ha SW
• Han JH
• Cho EK
• Kim DE

Abstract

Peripheral neuropathy has been uncommon reported as one of neurologic adverse effects associated with phenytoin. A 53 year-old man presented with clinical and electrophysiologic signs of peripheral neuropathy after 13 years of phenytoin administration. Despite a modest dose of phenytoin (300 mg/day), blood level was 40 microg/ml. After discontinuing phenytoin about eight months, the peripheral neuropathy was improved. We present a case of reversible peripheral neuropathy caused by chronic phenytoin intoxication.

Keyword

Phenytoin; Reversible peripheral neuropathy; Intoxication

MeSH Terms

Humans
Middle Aged
Peripheral Nervous System Diseases*
Phenytoin*
Phenytoin