J Korean Neurol Assoc.
1999 May;17(3):452-455.
Myasthenia Gravis in Two Brothers with Identical HLA Genotype
- Affiliations
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- 1Department of Neurology, Chungnam National University Hospital, Taejon, Korea.
Abstract
- Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction having multigene control. Correlation with human leukocyte antigen (HLA) genotype in MG had been reported in sporadic and familial cases. We investigated HLA genotype of two myasthenic brothers, at ages 13 and 15 years old. There was no family history of myasthenia gravis. Their ages of onset were 10 and 15 years of age, respectively. Identical subtypes in HLA analyses were found, A30, A31, B13, B61, Cw3, Cw6, DRB1*04, DRB1*07, DQA1*02, DQA1*03, DQB1*03, DQB1*02 in both of them. We report two myasthenic siblings with identical HLA type that has not been reported previously.
