J Korean Neurol Assoc.  1999 May;17(3):347-351.

Comparison of Antiplatelet Aggregation Effect between the High-Dose and Low-Dose Ticlopidine: A Preliminary Study

• Kim JM
• Kim J
• Song HJ
• Lee HB
• Lee TY

Abstract

BACKGROUND: To investigate the efficacy of antiplatelet activity of low dose ticlopidine, we compared the antiplatelet effect of low dose ticlopidine with a high dose.
METHODS
Fourteen healthy volunteers were divided into two series. Volunteers in series I were medicated ticlopidine 250 mg twice a day (group 1) for first 7 days. After drug free interval for another 7 days, single dose of ticlopidine 250 mg a day (group 2) was medicated for the third 7 days. Same medica-tion schedule was taken with different doses in series II, single dose of 250 mg ticlopidine (group 3) for the first 7 days, and divided dose of ticlopidine 250 mg a day (group 4) for the third 7 days after medication free interval of 7 days. Platelet aggregation effect was evaluated by optical method using ADP and collagen reagent at before and after the medication schedule. Differences of platelet aggregation effect between the four groups were analyzed.
RESULTS
Five and 4 could accomplish the full medication schedule of two groups in each series. Mean of platelet aggregation effect of group 1 (44.4%) was more decreased than other groups, 61.2% in group 2, 71.0% in group 3, and 62.7% in group 4. However, there was no significant differences of platelet aggregation effect by nonparametric statistical analysis between group 1 and 2, 3 and 4 in each series.
CONCLUSIONS
This finding suggests that single low dose ticlopidine may have the similar antiplatelet aggregation effect as the high dose one.

Keyword

Low dose ticlopidine; High dose ticlopidine; Platelet aggregation effect

MeSH Terms

Adenosine Diphosphate
Appointments and Schedules
Collagen
Healthy Volunteers
Platelet Aggregation
Ticlopidine*
Volunteers
Adenosine Diphosphate
Collagen
Ticlopidine