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Pantoprazole Does Not Reduce the Antiplatelet Effect of Clopidogrel: A Randomized Controlled Trial in Korea

Choi YJ, Kim N, Jang IJ, Cho JY, Nam RH, Park JH, Jo HJ, Yoon H, Shin CM, Park YS, Lee DH, Jung HC

BACKGROUND/AIMS: Concerns that proton pump inhibitors (PPIs) diminish the efficacy of clopidogrel could hamper the appropriate prescription of PPIs. We evaluated the influence of pantoprazole on the antiplatelet effect of...
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Thulium laser vaporesection of the prostate: Can we operate without interrupting oral antiplatelet/anticoagulant therapy?

Sener TE, Butticè S, Macchione , Netsch C, Tanidir Y, Dragos L, Pappalardo R, Magno C

PURPOSE: Thulium vaporesection of the prostate (ThuVARP) is a new and safe approach for patients receiving anticoagulant therapy in whom transurethral resection of the prostate (TURP) may possess a high...
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Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines

Kim S, Yun YM, Chae HJ, Cho HJ, Ji M, Kim IS, Wee KA, Lee W, Song SH, Woo HI, Lee SY, Chun S

Pharmacogenetic testing for clinical applications is steadily increasing. Correct and adequate use of pharmacogenetic tests is important to reduce unnecessary medical costs and adverse patient outcomes. This document contains recommended...
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Correlation Between the CYP2C19 Phenotype Status and the Results of Three Different Platelet Function Tests in Cardiovascular Disease Patients Receiving Antiplatelet Therapy: An Emphasis on Newly Introduced Platelet Function Analyzer-200 P2Y Test

Li S, Choi JL, Guo LZ, Goh RY, Kim BR, Woo KS, Kim MH, Han JY

BACKGROUND: An association has been reported between CYP2C19 polymorphism and the altered antiplatelet activity of clopidogrel. We investigated this association using the newly introduced platelet function analyzer (PFA)-200 (INNOVANCE PFA-200...
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Comparison of Angiographic Outcomes of Side Branch Ostium at Bifurcation Coronary Lesion between Two-stent and One-stent Techniques

Seo JB, Park KW, Lee HY, Kang HJ, Koo BK, Kim SH, Kim HS

Although the favored strategy for coronary bifurcation intervention is stenting main vessel with provisional side branch (SB) stenting, we occasionally use two-stent strategy. The objective of this study was to...
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Successful Management of Recurrent Colon Ulcer in Hemodialysis Patient after Conversion to Peritoneal Dialysis

Lee JY, Moon IT, Lee HY, Lee HL, Han DS

Lower gastrointestinal complications often develop in end stage renal disease patients, and among the more problematic is recurrent colon ulcer. The exact pathogenesis of this condition is not known and...
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Clinical Impact of Dual Antiplatelet Therapy on Peptic Ulcer Disease

Ahn DG, Kim BJ, Kim JW, Kim JG

BACKGROUND/AIMS: Increased incidence of coronary artery disease has led to the increased use of dual antiplatelet therapy composed of aspirin and clopidogrel. We investigated the incidence of gastrointestinal complications in...
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Does Dual Antiplatelet Therapy Increase the Risk of Peptic Ulcer Disease?

Kim JJ, Kim N

No abstract available.
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Antiplatelet Effect of Clopidogrel Can Be Reduced by Calcium-Channel Blockers

Seo KD, Kim YD, Yoon YW, Kim JY, Lee KY

PURPOSE: Clopidogrel is metabolized by the hepatic cytochrome P450 (CYP) system into its active thiol metabolite. CYP3A4 is involved in the metabolism of both clopidogrel and dihydropyridine calcium channel blockers...
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Efficacy and safety of antiplatelet-combination therapy after drug-eluting stent implantation

Cho YK, Nam CW, Park HS, Yoon HJ, Kim H, Hur SH, Kim YN, Lee JH, Yang DH, Lee BR, Jung BC, Kim W, Park JS, Lee JB, Kim KS, Kim KB

BACKGROUND/AIMS: Combination single-pill therapy can improve cost-effectiveness in a typical medical therapy. However, there is a little evidence about the efficacy and tolerability of combination single-pill antiplatelet therapy after percutaneous...
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Delayed Cerebral Infarction due to Stent Folding Deformation Following Carotid Artery Stenting

Seo KD, Lee KY, Kim BM, Suh SH

We report a case of delayed cerebral infarction due to stent longitudinal folding deformation following carotid artery stenting using a self-expandable stent with an open-cell design. The stented segment of...
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The Influence of Hypothermia on Transfusion Requirement in Patients Who Received Clopidogrel in Proximity to Off-Pump Coronary Bypass Surgery

Lee BR, Song JW, Kwak YL, Yoo KJ, Shim JK

PURPOSE: Hypothermia adversely affects the coagulation that could be of clinical significance in patients receiving clopidogrel. We evaluated the influence of hypothermia on transfusion requirements in patients undergoing isolated off-pump...
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Optimal Anticoagulation during Off Pump Coronary Artery Bypass in Patients Recently Exposed to Clopidogrel

Song Y, Song JW, Shim JK, Kwak YL

PURPOSE: The aim of this study was to find an optimal range of activated clotting time (ACT) during off-pump coronary artery bypass surgery (OPCAB) yielding ischemic protection without the risk...
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Genotype- and Phenotype-Directed Personalization of Antiplatelet Treatment in Patients with Non-ST Elevation Acute Coronary Syndromes Undergoing Coronary Stenting

Ahn SG, Yoon J, Kim J, Uh Y, Kim KM, Lee JH, Lee JW, Youn YJ, Ahn MS, Kim JY, Yoo BS, Lee SH, Tahk SJ, Choe KH

BACKGROUND AND OBJECTIVES: We evaluated the effectiveness of genotype- and phenotype-directed individualization of P2Y12 inhibitors to decrease high on-treatment platelet reactivity (HOPR). SUBJECTS AND METHODS: Sixty-five patients undergoing percutaneous coronary intervention...
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Management of Perioperative Antiplatelet Therapy

Oh SK

  • KMID: 2267823
  • Korean J Med.
  • 2013 Jul;85(1):22-28.
Drug-eluting stent (DES) implatation was the major method of coronary revascularization and marked reduction in target-lesion revascularization. Stent thrombosis (ST) is a severe complication that is associated with a high...
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New Oral Antiplatelet Agents

Kang MK, Chang K

  • KMID: 2267821
  • Korean J Med.
  • 2013 Jul;85(1):10-14.
Antiplatelet agents play an essential role in the treatment of acute coronary syndrome (ACS). Aspirin and thienopyridines comprise the major classes of antiplatelet therapies demonstrated to be of benefit in...
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Clopidogrel Resistance

Jeong YH

  • KMID: 2267820
  • Korean J Med.
  • 2013 Jul;85(1):1-9.
Platelet activation and aggregation play important roles in ischemic event occurrences in high-risk patients with coronary artery disease (CAD). Dual antiplatelet therapy with aspirin and a P2Y12 receptor inhibitor is...
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Pulmonary Alveolar Hemorrhage after Clopidogrel Use for ST Elevation Myocardial Infarction

Kim Y, Lim J, Lim J, Kim S, Jung T, Choi W

Combination treatment of antiplatelet drugs containing aspirin and clopidogrel reduces systemic ischemic events after percutaneous coronary intervention (PCI) in high risk patients. However, this combination treatment of antiplatelet drugs is...
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Spontaneous Spinal Epidural Hematoma Caused by Dual Antiplatelet Agent Therapy after Percutaneous Coronary Intervention

Kim SW, Yoo H, Song YJ, Han DH, Kim JH, Choi EJ, Lee N

  • KMID: 2267853
  • Korean J Med.
  • 2013 May;84(5):718-722.
Spontaneous spinal epidural hematomas (SSEH) are rare, accounting for less than 1% of all spinal epidural lesions. The potential causes include coagulopathies, antithrombotic drugs, hypertension, increased venous pressure, and vascular...
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Successful Prasugrel Rescue Therapy in Clopidogrel Resistant Patients Who Had Recurrent Stent Thrombosis of Drug-Eluting-Stent: The Role of Prasugrel in Clopidogrel Nonresponders

Lee SH, Kim BK, Oh J, Park JS, Lee DJ, Lee HC, Kim JH, Hong MK

Stent thrombosis is a very serious problem after drug-eluting stent (DES) implantation even though its incidence is about or less than 1%. As the clopidogrel resistance is expected to play...
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