Gut Liver.  2013 Sep;7(5):519-523.

Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms

• Kim ER
• Yang MH
• Lim YJ
• Lee JH
• Chang DK
• Kim YH
• Son HJ
• Kim JJ
• Rhee JC
• Kim JY

Abstract

BACKGROUND/AIMS
Plasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas.
METHODS
We reviewed the medical records of 3,136 subjects who underwent colonoscopy as a screening exam. The subjects were classified into a case group with adenomas (n=990) and a control group (n=2,146). Plasma PAI-1 levels were categorized into three groups based on tertile.
RESULTS
The plasma levels of PAI-1 were significantly higher in adenoma cases than in controls (p=0.023). The prevalence of colorectal adenomas increased significantly with increasing levels of PAI-1 (p=0.038). In the adenoma group, advanced pathologic features, size, and number of adenomas did not differ among the three groups based on tertiles for plasma PAI-1 levels. Using multivariate analysis, we found that plasma level of PAI-1 was not associated with the risk of colorectal adenomas (p=0.675). Adjusted odds ratios for colorectal adenomas according to increasing plasma levels of PAI-1 were 0.980 (95% confidence interval [CI], 0.768 to 1.251) for the second-highest plasma level and 1.091 (95% CI, 0.898 to 1.326) for the highest level, compared with the lowest levels.
CONCLUSIONS
These results suggest that elevated plasma PAI-1 levels are not associated with the risk of colorectal neoplasms.

Keyword

Plasminogen activator inhibitor 1; Colorectal neoplasms

MeSH Terms

Adenoma
Colonoscopy
Colorectal Neoplasms
Mass Screening
Medical Records
Multivariate Analysis
Neoplasm Metastasis
Odds Ratio
Plasma
Plasminogen
Plasminogen Activator Inhibitor 1
Plasminogen Activators
Prevalence
Plasminogen
Plasminogen Activator Inhibitor 1
Plasminogen Activators