Endocrinol Metab.  2013 Mar;28(1):26-32. 10.3803/EnM.2013.28.1.26.

Association between Serum Albumin, Insulin Resistance, and Incident Diabetes in Nondiabetic Subjects

Affiliations
  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 2Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. okwendo@yahoo.co.kr

Abstract

BACKGROUND
Serum albumin has been suggested to be associated with insulin resistance. We evaluated the association between serum albumin concentration and insulin resistance. We also investigated whether serum albumin level has an independent effect on the development of diabetes.
METHODS
In our study, 9,029 subjects without diabetes, who underwent comprehensive health check-ups annually for 5 years, were categorized into tertiles based on their serum albumin levels at baseline. The odds ratio (OR) for the prevalence of insulin resistance, defined as the top quartile of homeostasis model assessment of insulin resistance and the presence of impaired fasting glucose and nonalcoholic fatty liver disease, was evaluated cross-sectionally. Also, the hazard ratio (HR) for incident diabetes was estimated longitudinally, according to the baseline albumin tertiles using Cox proportional hazard analysis respectively.
RESULTS
From the lowest to the highest tertile of albumin, the multivariable-adjusted ORs of insulin resistance increased significantly in both men and women. During the mean follow-up period of nearly 4 years, 556 (6.1%) subjects progressed to diabetes. The multivariable-adjusted HR (95% confidence interval [CI]) of diabetes in men were 1, 1.09 (95% CI, 0.86 to 1.40), and 1.10 (95% CI, 0.86 to 1.41), respectively, from the lowest to the highest tertiles of baseline albumin. Corresponding values for women were 1, 1.21 (95% CI, 0.66 to 2.21), and 1.06 (95% CI, 0.56 to 2.02), respectively.
CONCLUSION
Our study showed that increased serum albumin level was associated with insulin resistance. However, serum albumin did not have an independent effect on the development of diabetes.

Keyword

Serum albumin; Insulin resistance; Diabetes

MeSH Terms

Electrolytes
Fasting
Fatty Liver
Female
Follow-Up Studies
Glucose
Homeostasis
Humans
Insulin
Insulin Resistance
Male
Odds Ratio
Prevalence
Serum Albumin
Electrolytes
Fatty Liver
Glucose
Insulin
Serum Albumin

Cited by  2 articles

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You-Bin Lee, Ji Eun Jun, Seung-Eun Lee, Jiyeon Ahn, Gyuri Kim, Jae Hwan Jee, Ji Cheol Bae, Sang-Man Jin, Jae Hyeon Kim
Diabetes Metab J. 2018;42(6):529-537.    doi: 10.4093/dmj.2018.0012.

Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
Won-Young Lee
Endocrinol Metab. 2014;29(3):251-256.    doi: 10.3803/EnM.2014.29.3.251.


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