Yonsei Med J.  2014 Sep;55(5):1214-1221. 10.3349/ymj.2014.55.5.1214.

Prognostic Value of Sex-Hormone Receptor Expression in Non-Muscle-Invasive Bladder Cancer

• Nam JK
• Park SW
• Lee SD
• Chung MK

• KMID: 1799483
• DOI: http://doi.org/10.3349/ymj.2014.55.5.1214

Abstract

PURPOSE
We investigated sex-hormone receptor expression as predicting factor of recurrence and progression in patients with non-muscle invasive bladder cancer.
MATERIALS AND METHODS
We retrospectively evaluated tumor specimens from patients treated for transitional cell carcinoma of the bladder at our institution between January 2006 and January 2011. Performing immunohistochemistry using a monoclonal androgen receptor antibody and monoclonal estrogen receptor-beta antibody on paraffin-embedded tissue sections, we assessed the relationship of immunohistochemistry results and prognostic factors such as recurrence and progression.
RESULTS
A total of 169 patients with bladder cancer were evaluated in this study. Sixty-threepatients had expressed androgen receptors and 52 patients had estrogen receptor beta. On univariable analysis, androgen receptor expression was significant lower in recurrence rates (p=0.001), and estrogen receptor beta expression was significant higher in progression rates (p=0.004). On multivariable analysis, significant association was found between androgen receptor expression and lower recurrence rates (hazard ratio=0.500; 95% confidence interval, 0.294 to 0.852; p=0.011), but estrogen receptor beta expression was not significantly associated with progression rates.
CONCLUSION
We concluded that the possibility of recurrence was low when the androgen receptor was expressed in the bladder cancer specimen and it could be the predicting factor of the stage, number of tumors, carcinoma in situ lesion and recurrence.

Keyword

Androgen receptor; estrogen receptor beta; urinary bladder neoplasms

MeSH Terms

Adult
Aged
Aged, 80 and over
Carcinoma, Transitional Cell/*metabolism/pathology
Disease Progression
Disease-Free Survival
Female
Humans
Male
Middle Aged
Multivariate Analysis
Neoplasm Invasiveness
Prognosis
Receptors, Androgen/*metabolism
Receptors, Estrogen/*metabolism
Retrospective Studies
Risk Factors
Tumor Markers, Biological/*metabolism
Urinary Bladder Neoplasms/*metabolism/pathology
Young Adult
Receptors, Androgen
Receptors, Estrogen
Tumor Markers, Biological

Figure

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  Fig. 1 Immunohistochemical staining of androgen receptor (A) and estrogen receptor beta (B). (A) Diffuse, strong nuclear staining in low grade papillary tumor (×400). (B) Strong nuclear staining in high grade urothelial tumor (×400).

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  Fig. 2 Kaplan-Meier estimated recurrence-free survival probability of androgen receptor (A), estrogen receptor beta (B), and progression-free survival probability of androgen receptor (C), estrogen receptor beta (D). AR, androgen receptor; ER, estrogen receptor.

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